In diagnostica, le concentrazioni di lattoferrina nelle fecipossono essere valutate per ricercare la presenza di malattie infiammatorie intestinali, come il morbo di Crohne la colite ulcerosa. Queste patologie, infatti, si accompagnano tipicamente a un aumento della lattoferrina fecale. Birgens HS (April 1985). "Lactoferrin in plasma measured by an ELISA technique: evidence that plasma lactoferrin is an indicator of neutrophil turnover and bone marrow activity in acute leukaemia". Scandinavian Journal of Haematology. 34 (4): 326–31. doi: 10.1111/j.1600-0609.1985.tb00757.x. PMID 3858982.

Tsuda H, Sekine K, Fujita K, Ligo M (2002). "Cancer prevention by bovine lactoferrin and underlying mechanisms--a review of experimental and clinical studies". Biochemistry and Cell Biology. 80 (1): 131–6. doi: 10.1139/o01-239. PMID 11908637. Kuipers ME, de Vries HG, Eikelboom MC, Meijer DK, Swart PJ (November 1999). "Synergistic fungistatic effects of lactoferrin in combination with antifungal drugs against clinical Candida isolates". Antimicrobial Agents and Chemotherapy. 43 (11): 2635–41. doi: 10.1128/AAC.43.11.2635. PMC 89536. PMID 10543740. Lactoferrin levels in tear fluid have been shown to decrease in dry eye diseases such as Sjögren's syndrome. [80] A rapid, portable test utilizing microfluidic technology has been developed to enable measurement of lactoferrin levels in human tear fluid at the point-of-care with the aim of improving diagnosis of Sjögren's syndrome and other forms of dry eye disease. [81] Nanotechnology [ edit ]

ORIGINAL RESEARCH article

Zhao X, Zhang X, Xu T, Luo J, Luo Y, An P. Comparative Effects between Oral Lactoferrin and Ferrous Sulfate Supplementation on Iron-Deficiency Anemia: A Comprehensive Review and Meta-Analysis of Clinical Trials. Nutrients 2022;14(3):543. View abstract.

Liao Y, Lopez V, Shafizadeh TB, Halsted CH, Lönnerdal B (November 2007). "Cloning of a pig homologue of the human lactoferrin receptor: expression and localization during intestinal maturation in piglets". Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology. 148 (3): 584–90. doi: 10.1016/j.cbpa.2007.08.001. PMC 2265088. PMID 17766154. Xavier PL, Chaudhari K, Verma PK, Pal SK, Pradeep T (December 2010). "Luminescent quantum clusters of gold in transferrin family protein, lactoferrin exhibiting FRET" (PDF). Nanoscale. 2 (12):Despite the sudden peak in the related studies in the literature in the last 3 years due to the pandemic, Lf still hasn't gotten the attention it deserves in the COVID-19 studies. Although the main focus of COVID-19 studies is on the prevention with vaccines, the effect of Lf on the immune system to prevent COVID-19 and the synergistic studies with vaccines are almost non-existent. The previous studies on Lf mainly focus on the treatment potential of Lf. On the other hand, despite the early studies on Lf effects on COVID-19 studies not only put forth promising results but also showed comparable or even better results than traditional treatment strategies such as SOC, there are still not enough studies on the treatment potential of this multifunctional protein.